Clomid (clomiphene) is a nonsteroidal infertility cure. It helps the hypophysis to trigger the production/release of hormones required to induce ovulation. This medicine is frequently used in females with specific physical alignments, including PCOS (Hyperandrogenic anovulation/ Stein–Leventhal syndrome) and other health issues that stop ovulation from happening. Clomid is a drug of a very significant potency. It’s proven to be among the best infertility therapies available. To put it simply, clomiphene alters the effects of estrogen in the female body.
This drug may also be used for causes that weren’t specified on this page.
History of Clomid
This drug has been around since the late ’60s. Back in the day, it was mainly used to treat oligomenorrhoea in females. After a few years, the doctors took note of the significantly increased pregnancy rates in women undergoing the treatment. From that point on, clomiphene was used for interfertility treatment. When talking about the history of fertility medicine in general, it’s important to note that back in the ’60s, a fertility doctor’s whole job was to refer couples to adoption agencies.
When you take that into consideration, it becomes impossible to exaggerate the importance of the aforementioned discovery. Clomid was a real breakthrough. To this very day, it remains among the most popular infertility treatments because of its effectiveness and relative safeness.
- You mustn’t use Clomid if you’re at increased risk of serious allergy-induced reactions to clomifene or in case you have:
- Abnormal uterine bleeding.
- Functional cyst on ovary.
- Liver issues.
You should also avoid using that drug if you already are impregnated. Just to ensure that this drug is 100% harmless for you, tell your MD if you have adenomyosis or uterine leiomyomas. Just to reiterate, it’s incredibly vital that you don’t take clomiphene while pregnant. Clomifene can cross into breast milk which might cause serious health issues for the baby. Also, this medicine is well-known to cause a major slowdown in milk supply in some females. Ensure that your therapist knows you are breastfeeding.
Using this drug for more than three courses increases your chances of getting ovarian cancer. Speak to your physician regarding this matter. This drug and other treatments for infertility, in general, may cause multiple births. You must realize that those types of pregnancies are always risky, both for the patient and the baby. You must talk to your physician before you start this treatment.
How do I take Clomid?
You must follow the doctor’s exact orders. Follow all requirements specified on the prescription label. The dosage might be changed if your physician thinks it will get you the best possible results. Never take bigger or smaller doses, never continue the treatment past the suggested point.Your MD has to conduct diagnostic procedures to ensure you don’t suffer from medical issues that would disrupt the safeness of your clomiphene treatment. This drug is normally taken for five days straight. The beginning point is Day Five of your menstruation period.
Manual uterine palpation is required every time you start a new treatment course. You must be under a physician’s care while you are undergoing this treatment. Your ovulation will start in the span of five to ten days after you begin taking this drug. To significantly improve your chances of getting pregnant, you must engage in coitus with your partner during the ovulation. Your physician needs to check your temperature daily, in the morning. All the data has to be recorded. This way, your MD can predict when the ovulation will happen.
In all likelihood, this drug won’t be used for more than three treatment cycle. If the impregnation still doesn’t happen after three cycles, your physician will reevaluate your fertility to suggest a different way
Under the normal circumstances, the drug is taken for five days straight. You take a 50mg. dose by mouth. The therapy normally starts on the fifth day of the menstruation. It can be initiated at any point in females who didn’t experience dysfunctional uterine bleeding recently. If the female doesn’t get pregnant even though the ovulation occurs, a physician can up to two added cycles of 50mg. treatment (one dose per day, five days in a row).
There has to be a break between each course, approximately 29 days. In most women, the ovulation does occur after the very first cycle, but if the female in question fails to ovulate, a physician usually increases the dosage during the second round of treatment – patients now take 100 mg. a day, five days in a row. Once again, there has to be a break – approximately 29 days. A third course may be required after 29 days, as well.
There have been cases of successful pregnancies with 200 mg. dosages are taken for five days straight or with prolonged ten-day therapy or in females receiving more than three treatment cycles. However, it must be noted that this goes against the manufacturer’s recommendations and could possibly lead to serious consequences.
The dosage required to stop the milk production:
- 50mg-100mg by mouth, once per day, five days in a row. Under most circumstances, one treatment cycle is more than enough.
The dosage required to treat oligozoospermia:
- 25mg-100mg by mouth, once per day. This treatment is usually spread out over the period of several months.
You must store clomiphene at room temperature (15-30C/ 59-86F). It must be kept away from warmth, humidity, sunlight. It must be kept away from children and pets.
Along with the intended effects, you may encounter some adverse effects. Although it’s unlikely that these unwanted effects will actually occur, if they do – they might require medical attention. Here are the most common side-effects encountered while on this drug. We’ve decided to split them into different categories, for your convenience.
Nervous system related: vertigo, headache, wooziness, slowness, depression, hypererethism, insomnia. Digestive system related: nausea, vomiting, gastralgia, flatulence, diarrhea.
Allergic reactions: rash, allergodermia, vasculomotor issues.
Genitourinary system related: polyuria, frequent urination, abdominal pains, dysmenorrhea, hypermenorrhea.
Miscellaneous: weight gain, flushing, eyesight issues, chest pains, yellow skin, diplopia, photophobia. It’s not a full list of all adverse effects, you must be wary of the fact the everyone reacts differently. Please stay safe and contact your physicians if you encounter any of the aforementioned symptoms.
The most commonly encountered side-effect: bloating. The rarest adverse reactions: restlessness, heavy bleeding between periods, discomfort in the breast area, cephalgia. You must notify your physician regarding any and all adverse effects which you encounter, but you don’t have to worry. Most of the above-mentioned issues will eventually go away once your body is done readjusting. In general, this drug has some of the mildest adverse reactions when compared to the alternatives.
If you take too much clomiphene, you should call your nearest Poison Control Center or nearest hospital right away. The early signs of overdose: severe headaches, vomiting, flushing, flashes of red, issues with the eyesight (namely: blurred vision) and painful sensations in the chest area.
Luckily, there aren’t that many drugs that interact with Clomid. That means we can get a more in-depth analysis of the interactions themselves.
Bexarotene (trade name: Targretin) is an anti-cancer treatment, it has been approved by the FDA in 1999. It’s used to treat granuloma fungoides, is the most prevalent type of T-cell lymphoma. When taken with clomiphene, this drug increases the chances of a patient encountering inflammation of the pancreas. There’s a major interaction between the two drugs, so you should definitely talk to your physician before mixing the two. Your MD may be able to suggest an alternative. Common symptoms of pancreatitis include: barfing, wooziness, tenderness in the stomach area and several others.
Ospemifene (Osphena) is a drug used to treat dyspareunia. Dyspareunia is a term used to describe painful intercourse. The both of these medications have similar effects on the body, so their combined effect may severely increase the risk of unwanted adverse effects, including stroke, coagulation, and some types of cancer. You must immediately call for help if you encounter any of the symptoms mentioned here: swollen arms/legs, sternal pain, stethalgia, respiratory distress.
Some drugs can interact with certain foods. In this case, there are no foods that you need to avoid while undergoing this treatment.
How to Increase Its Effectiveness?
Once again, you need to follow all the instructions specified by the doctor. One of the most important things that patients tend to overlook: you must engage in an intercourse every other day starting from Day 7. Men usually take approximately 48 hours to build up enough sperm to get a woman pregnant, so having intercourse every single day is not advised. The daily intercourse may also harm your chances of getting pregnant during the following treatment circles.
- If you involuntarily skip a dose of clomiphene, you should contact your physician immediately. This treatment is of utmost importance, so there’s almost no room for error.
- You should avoid driving. This drug can cause blurred vision and several other visual adverse effects.
- You should avoid operating heavy machinery. This task requires alertness which may or may not decrease while you’re undergoing this treatment.
- You should avoid performing any hazardous activities. Same as before, your vision may be affected as well as your alertness. This drug is manufactured by Sanofi-Aventis U.S. LLC.
- There are no major differences between brand-name drugs and its generic version.
- You should limit your alcohol intake while undergoing this treatment. Talk to your MD for more information.
This was my first infertility treatment. It’s my last infertility treatment too by the way. We tried to start a family and we succeeded, thanks to this drug. I had pretty hardcore eye issues while taking it, though. Had to wear shades most of the time, because of this extra-sensitivity to light. What else…. Yeah, my libido was through the roof at the time. All in all, it’s hard to objective when a drug was this life-changing. I’m giving Clomid 10/10. Good luck to you all! Kids are great (not so much during the first two years).
Trying to conceive for 9 years… I was unfortunate enough. At the age of 29, I was diagnosed with PCOS. As per the doctor’s suggestion, I purchased Clomid. I wasn’t able to ovulate on my own, so during the first treatment circle I was able to ovulate but did not get pregnant. The second cycle was hard, I actually got pregnant but miscarried at 10 weeks. It took some counseling and lots of talking, but I eventually decided to give Clomid one last try…. And now I have a beautiful daughter, a healthy and happy 8 moth old!
So now I’m 30, I have a 3.5-year-old daughter. My hubby wants more kids and we’ve been trying to get pregnant during the last couple of years. Sadly, all failed attempts – miscarriages. Then in January 2016, my fertility doctor prescribed me Clomid. Purchased the generic version via the internet. I know it was risky, but I was in a bad place at the time. So, to make a long story slightly shorter: IT WORKED. In May 2016, we were able to conceive. Now I have two kids, never been happier!!!
The first cycle worked for me!! I’m in shock. Before I actually purchased Clomid, I made sure I do some internet sleuthing. Read some success stories, some sad tales of miscarriages, the usual. Figured I won’t get pregnant during the first cycle. I’m still in shock, honestly. Ten positive pregnancy tests later, I’m 100% sure that I’m pregnant and I just cannot believe my luck. This is the best medicine for women with PCO issues. I am so excited, I’m gonna be a mom real soon!